ATVB in focus. Monocyte subsets and their relevance to cardiovascular diseases. Editorial.
نویسنده
چکیده
The aim of this overview is to summarize the available data on the involvement of monocytes in the pathological processes related to the development of acute coronary syndromes and the recovery of damaged areas, the prevention of excessive inflammatory and procoagulant response, and the restoration of microcirculation (angiogenesis). (Arterioscler Thromb Vasc Biol. 2009;29:1433-1438.)
منابع مشابه
ATVB In Focus Monocyte Subsets and Their Relevance to Cardiovascular Diseases
Monocytes and macrophages play active roles in atherosclerosis, a chronic inflammatory disease that is a leading cause of death in the developed world. The prevailing paradigm states that, during human atherogenesis, monocytes accumulate in the arterial intima and differentiate into macrophages, which then ingest oxidized lipoproteins, secrete a diverse array of proinflammatory mediators, and e...
متن کاملMacrophages.
Thanks to major advances in cellular and molecular biology, our understanding of the origins, heterogeneity, and functions of monocytes and macrophages, both in health and disease, is evolving at a considerable pace. Only during the past 2 years, new monocyte and dendritic cell subsets have been identified; essential transcriptional and epigenetic regulators of monocyte and tissue macrophage sp...
متن کاملMonocyte Activation/Recruitment and Macrophage Trapping Within the Lesions
Macrophages are the building blocks of intimal atherosclerotic lesions where they scavenge and accumulate modified lipoproteins, profoundly affecting lesion development and progression through their roles in lipid metabolism and as major sensors and effectors of the innate immune system. Lesional macrophages originate from circulating monocytes, although more recent work indicates that a subpop...
متن کاملMonocyte Activation/Recruitment and Macrophage Trapping Within the Lesions
Macrophages are the building blocks of intimal atherosclerotic lesions where they scavenge and accumulate modified lipoproteins, profoundly affecting lesion development and progression through their roles in lipid metabolism and as major sensors and effectors of the innate immune system. Lesional macrophages originate from circulating monocytes, although more recent work indicates that a subpop...
متن کاملHeterogeneity of Bovine Peripheral Blood Monocytes
Peripheral blood monocytes of several species can be divided into different subpopulations with distinct phenotypic and functional properties. Herein, we aim at reviewing published work regarding the heterogeneity of the recently characterized bovine monocyte subsets. As the heterogeneity of human blood monocytes was widely studied and reviewed, this work focuses on comparing bovine monocyte su...
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ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 29 10 شماره
صفحات -
تاریخ انتشار 2009